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Search Results for " death-domain associated protein "

3

抑制剂 & 化合物

13

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T38339	R-8507
	R-8507 is a small molecule antagonist of the TNF-α type 1 receptor (TNF-αRI). It inhibits the expression of intercellular adhesion molecule-1 (ICAM-1) induced by TNF-α and IL-1β with EC50 values of 2.45 and 3.79 μM, respectively, in an ELISA using A549 lung epithelial cells.{\|Gururaja2007\|} It also disrupts the interaction of the TNF-αRI with receptor interacting protein 1 (RIP1) and TNF-αR-associated death domain protein (TRADD), preventing internalization of the receptor complex.
T80222	TAT-BH4 (Bcl-xL) (TFA)	Apoptosis	Apoptosis
	TAT-BH4 (Bcl-xL) TFA 主要定位于线粒体，具有阻止细胞凋亡的功能。该化合物含有标记有N端伊红的半胱氨酸，以及融合了HIV TAT蛋白的protein transduction domain（氨基酸49至57）的Bcl-xL BH4肽。TAT-BH4 TFA常用于研究由细胞凋亡加速引起的疾病。
T82368	FTO-IN-10	Autophagy	Autophagy
	FTO-IN-10（化合物7）是一种针对人类去甲基酶FTO（脂肪量和肥胖相关蛋白）的有效抑制剂，其IC50值为4.5 μM。该化合物通过疏水作用和氢键相互作用与FTO的结构域II的结合口袋相结合。在A549细胞中，FTO-IN-10能够诱导DNA损伤和自噬性细胞死亡。

化合物

Cat.No: T38339

TAT-BH4 (Bcl-xL) (TFA)

Cat.No: T80222

Target: Apoptosis

Cat.No: T82368

Target: Autophagy

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00047	Dengue virus DENV-2 (Strain New Guinea C) Capsid protein/DENV-C Protein (His) death-domain associated prote...	DENV	E. coli
	Dengue virus DENV-2 (Strain New Guinea C) Capsid protein/DENV-C Protein (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 14 kDa and the accession number is W0GCK5.
TMPJ-01059	CRADD Protein, Human, Recombinant Caspase and RIP Adapter with Death Domain,...	Human	E. coli
	Death Domain-Containing Protein CRADD (CRADD) is widely expressed in most tissues, with particularly high expression in the adult heart, testis, liver, skeletal muscle, fetal liver, and kidney. CRADD contains one CARD domain that mediates the interaction with caspase-2, and one death domain involved in the binding of RIP protein. CRADD functions as an apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. CRADD induces cell apoptosis/cell death in numero...
TMPJ-01256	Caspase-10 Protein, Human, Recombinant (His) CASP10,FAS-Associated Death Domain	Human	E. coli
	Caspase-10 (CASP10) is a 521 amino acid protein member of the Cysteine-Aspartic Acid Protease (Caspase) family. CASP10 contains two DED (Death Effector) domains and is detectable in most tissues. CASP10 cleavage by Granzyme B and autocatalytic activity generate the two active subunits: Caspase-10 subunit p23/17, Caspase-10 subunit p12. Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the execution-phase of cell apoptosis, the initiation and execution. Human ca...
TMPY-04483	IRAK4 Protein, Human, Recombinant (His) IPD1,NY-REN-64,REN64,interleukin-1 receptor-associated	Human	Baculovirus Insect Cells
	Interleukin-1 receptor-associated kinase 4, also known as Renal carcinoma antigen NY-REN-64, IRAK-4, and IRAK4, is a member of the protein kinase superfamily, TKL Ser/Thr protein kinase family, and Pelle subfamily. IRAK4 contains one death domain and one protein kinase domain. IRAK4 is required for the efficient recruitment of IRAK1 to the IL-1 receptor complex following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. ...
TMPJ-00854	ETS1 Protein, Human, Recombinant (His) V-ets Erythroblastosis Virus E26 Oncogene Homolog 1 (Avian),...	Human	E. coli
	ETS1 Protein (ETS1) is a nuclear protein that belongs to the ETS family. Members of this family recognize the core consensus DNA sequence GGAA/T in target genes. Proteins function either as transcriptional activators or repressors of numerous genes. They are involved in stem cell development, cell senescence and death, and tumorigenesis. ETS1 is a transcription factor, containing one ETS DNA-binding domain and one PNT (pointed) domain. it has been shown to interact with TTRAP, UBE2I and Death As...
TMPY-02213	RAIDD Protein, Human, Recombinant (His) RAIDD,MRT34,CASP2 and RIPK1 domain containing adapt...	Human	E. coli
	Death domain-containing protein CRADD, also known as Caspase and RIP adapter with death domain, RIP-associated protein with a death domain, CRADD and RAIDD, is a protein which is constitutively expressed in most tissues, with particularly high expression in adult heart, testis, liver, skeletal muscle, fetal liver and kidney. CRADD / RAIDD contains oneCARD domain and onedeath domain. CRADD / RAIDD contains a death domain involved in the binding of RIP protein. The CARD domain mediates the ...
TMPY-04417	DAPK1 Protein, Human, Recombinant (aa 1-363, His & GST) DAPK,death-associated protein kin...	Human	Baculovirus Insect Cells
	Death-associated protein kinase 1, also known as DAP kinase 1, DAPK1 and DAPK, is a cytoplasm protein which belongs to theprotein kinase superfamily, CAMK Ser / Thr protein kinase family and DAP kinase subfamily. DAPK1 contains tenANK repeats, onedeath domain and oneprotein kinase domain. DAPK1 is a calcium / calmodulin-dependent serine/threonine kinase which acts as a positive regulator of apoptosis. DAPK1 gene is a candidate tumor suppressor (TSG) and the abnormal methylation of DAPK1 g...
TMPY-02106	GAP43 Protein, Human, Recombinant (His) B-50,PP46,growth associated protein 43	Human	HEK293 Cells
	Neuromodulin, also known as Axonal membrane protein GAP-43, Growth-associated protein 43, Neural phosphoprotein B-5, pp46 and GAP43, is a cell membrane protein which belongs to theneuromodulin family. Neuromodulin / GAP43 contains oneIQ domain. Neuromodulin / GAP43 is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. Neuromodulin / GAP43 is involved in neurite outgrowth, a crucial process for the differentiation of n...
TMPJ-01211	EDA2R Protein, Mouse, Recombinant (His) EDA-A2R,Tumor necrosis factor receptor superfamily member XE...	Mouse	HEK293 Cells
	Tumor necrosis factor receptor superfamily member 27, also known as XEDAR and EDA2R, is a type III transmembrane protein of the TNFR superfamily. EDA2R consists of extracellular domain (ECD) with 3 cysteine-rich repeats and a single transmembrane domain but lacks an N-terminal signal peptide. EDA2R is widely expressed, notably in embryonic basal epidermal cells and maturing hair follicles. Even though it does not contain a cytoplasmic death domain, EDA2R can associate with Fas and induce EDA‑A2 ...
TMPY-03227	CISD1 Protein, Human, Recombinant (His) ZCD1,CDGSH iron sulfur domain 1,C10orf70,mitoNEET,M...	Human	E. coli
	Mitochondrial dysfunction is thought to play a significant role in neurodegeneration observed in Parkinson's disease (PD), the loss of mitoNEET (CISD1), an iron-sulfur containing protein that regulates mitochondrial bioenergetics, results in mitochondrial dysfunction and loss of striatal dopamine and tyrosine hydroxylase. CDGSH iron sulfur domain 1 (CISD1, also termed mitoNEET), an iron-containing outer mitochondrial membrane protein, negatively regulates ferroptotic cancer cell death. At the ce...
TMPJ-00455	SLAMF5 Protein, Mouse, Recombinant (His) CD84 molecule,SLAM family member 5,Leukocyte differentiation...	Mouse	HEK293 Cells
	CD84, also called SLAMF5, is a member of the CD2 subgroup of the immunoglobulin receptor superfamily. Members of this CD2 subgroup mediate signal transduction through the interaction of its immunoreceptor tyrosine-based switch motifs (ITSM) in the intracellular region and the SH2 domain of adaptor molecules SAP (SLAM-associated protein) and EAT-2 (EWS-activated transcript 2), and accordingly modulate both adaptive and innate immune responses. CD84 expression has been documented on several hemato...
TMPY-04385	ZIP Kinase/DAPK3 Protein, Human, Recombinant (GST) death-associated protein kinase 3...	Human	Baculovirus Insect Cells
	Death-associated protein kinase 3, also known as DAP kinase 3, ZIP-kinase, DAPK3 and ZIPK, is a nucleus and cytoplasm protein which belongs to theprotein kinase superfamily, CAMK Ser/Thr protein kinase family and DAP kinase subfamily. DAPK3 / ZIPK contains oneprotein kinase domain. It is a serine/threonine kinase which acts as a positive regulator of apoptosis. It phosphorylates histone H3 on 'Thr-11' at centromeres during mitosis. DAPK3 / ZIPK is a homodimer or forms heterodimers with AT...
TMPY-01416	OLFM4 Protein, Human, Recombinant (His) hGC-1,GC1,OLM4,bA209J19.1,GW112,olfactomedin 4,OlfD,hOLfD,UN...	Human	HEK293 Cells
	Olfactomedin-4, also known as G-CSF-stimulated clone 1 protein, Antiapoptotic protein GW112, and OLFM4, is a secreted protein that contains one olfactomedin-like domain. The OLFM4 gene was recently reported to inhibit various apoptotic pathways and promote the proliferation of cancer cells, suggesting that OLFM4 might serve as a diagnostic marker for human cancers. Thus, OLFM4 mRNA might be a useful tool to support the diagnosis of cancer, irrespective of the clinical stages. It is overexpressed...

重组蛋白

Dengue virus DENV-2 (Strain New Guinea C) Capsid protein/DENV-C Protein (His)

Cat.No: TMPY-00047

Species: DENV

Expression System: E. coli

CRADD Protein, Human, Recombinant

Cat.No: TMPJ-01059

Species: Human

Expression System: E. coli

Caspase-10 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01256

Species: Human

Expression System: E. coli

IRAK4 Protein, Human, Recombinant (His)

Cat.No: TMPY-04483

Species: Human

Expression System: Baculovirus Insect Cells

ETS1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00854

Species: Human

Expression System: E. coli

RAIDD Protein, Human, Recombinant (His)

Cat.No: TMPY-02213

Species: Human

Expression System: E. coli

DAPK1 Protein, Human, Recombinant (aa 1-363, His & GST)

Cat.No: TMPY-04417

Species: Human

Expression System: Baculovirus Insect Cells

GAP43 Protein, Human, Recombinant (His)

Cat.No: TMPY-02106

Species: Human

Expression System: HEK293 Cells

EDA2R Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01211

Species: Mouse

Expression System: HEK293 Cells

CISD1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03227

Species: Human

Expression System: E. coli

SLAMF5 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00455

Species: Mouse

Expression System: HEK293 Cells

ZIP Kinase/DAPK3 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04385

Species: Human

Expression System: Baculovirus Insect Cells

OLFM4 Protein, Human, Recombinant (His)

Cat.No: TMPY-01416

Species: Human

Expression System: HEK293 Cells

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